The colonic mucus barrier is commonly described as a continuous double layer covering the epithelium, separating the microbiota from the intestinal tissue. This model is currently considered valid.
Males had a high diabetes incidence that was increased by early overnutrition, characterized by a progressive increase in insulin secretion as well as β cell death, indicated by histological analysis.
1 Department of Pathology, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA 15213, USA. 2 Department of Medicine, University of Pittsburgh Medical Center, McKeesport, PA 15132, USA. 3.
Kidney sections were also stained with Periodic Acid Schiffs (PAS) stain or Periodic Acid Silver. As a result of the differences in spleen weights, the histology of the spleens was examined. No.
PLD couples survival and migration in tumor cell lines. 37 Overexpression of wild-type PLD2 has been implicated in EL4 lymphoma metastasis in vivo, whereas overexpression of catalytically inactive.
Gastrointestinal epithelial cells provide a selective barrier that segregates the host immune system from luminal microorganisms, thereby contributing directly to the regulation of homeostasis. We.
Cholestasis is a clinical disorder defined as an impairment of bile flow, and that leads to toxic bile acid (BA) accumulation in hepatocytes. which was supported by liver tissue histology, and.
The contribution of mast cells in the microenvironment of solid malignancies remains controversial. Here we functionally assess the impact of tumor-adjacent, submucosal mast cell accumulation in.
In the present studies, we hypothesized that colon IELs promote epithelial barrier function through the secretion of cytokines, particularly IL-6, stimulated by interactions with commensal microbes.
RNA polymerase III (Pol-III) transcribes tRNAs and other short non-coding RNAs that are important in protein production. Pol-III is the largest of the RNA polymerases containing 17 subunits, all.
The sections were stained with hematoxylin for negatively charged nucleic acid, counterstained with eosin for protein staining, then coverslipped with DPX (BDH, Poole, UK). The images were captured.
The functions of the IL-36 cytokines remain poorly understood. We report a previously unrecognized mechanism whereby IL-36 promotes innate antiviral immunity in mouse and human models of herpes.
Two of the most prominent figures in the debate over whether vaccines contribute to autism are coming to La Crosse. Andrew Wakefield, the English doctor who championed the now-dismissed link between.
Conversely, extended GLP-1 microbe intervention improved glucose-dependent insulin secretion, glucose metabolism and cholesterol metabolism, compared to the high-fat control group. Interestingly, the.
The diffuse-type gastric cancer (DGC) is a subtype of gastric cancer with the worst prognosis and few treatment options. Here we present a dataset from 84 DGC patients, composed of a proteome of.